Commercial
Advanced Search

​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​Services that require precertification for Independence Commercial Members (Effective 01/01/2025)​


Services that require precertification 


​As of January 1, 2025, this list applies to all Independence Blue Cross HMO, PPO, and POS products, including Flex products.  For Federal Employee Program (FEP) precertification requirements, please see the separate FEP precertification list. 

This applies to services performed on an elective, nonemergency basis 

Because a service or item is subject to precertification, it does not guarantee coverage. The terms and conditions of your benefit plan must be reviewed to determine if any of these services or items are excluded. 

You can find additional information regarding preapproval/precertification, member cost-sharing and prescription drug coverage on the Independence Preapproval/Precertification Requirements, Member Cost-Sharing, and Prescription Drug Formulary Lists page.


​All home-care services (including infusion therapy in the home) 


Inpatient services 


  • Acute rehabilitation admissions 
  • Elective surgical and nonsurgical inpatient admissions 
  • Inpatient hospice admissions 
  • Long term acute care (LTAC) facility admissions 
  • Skilled nursing facility admissions 

Cardiology procedures


Precertification is performed by Carelon Medical Benefits Management, an independent company. 

  • Arterial ultrasound 
  • Diagnostic coronary angiography 
  • Percutaneous coronary intervention 

Procedures​ 

  • Cochlear implant surgery and associated supplies/bone-anchored (osseointegrated) hearing aids, implantable bone conduction hearing aids

    69714, 69715, 6971​7, 69718, 69930, L8619, L8627, L8628, L8629, L8690, L8691, L8692, L8693
     
  • Obesity surgery

    43644, 43645, 43659, 43770, 43771, 43772, 43773, 43774, 43775, 43842, 43843, 43845, 43846, 43847, 43848, 43886, 43887, 43888, 43999
     

Musculoskeletal Procedures


Precertification is performed by Carelon Medical Benefits Management, an independent company.  For additional information, refer to the current version of Medical Policy #00.01.66: Musculoskeletal Services. 

  • Bone graft substitutes and bone morphogenetic proteins for spine surgery 
  • ​Cervical decompression with or without fusion​
  • Cervical disc arthroplasty​
  • Hip arthroplasty 
  • Hip arthroscopy and open procedures 
  • Knee arthroplasty 
  • Knee arthroscopy and open procedures 
  • Lumbar disc arthroplasty 
  • Lumbar discectomy, foraminotomy, and laminotomy 
  • Lumbar fusion and treatment of spinal deformity (including scoliosis and kyphosis) 
  • Lumbar laminectomy 
  • Meniscal allograft transplantation of the knee 
  • Shoulder arthroplasty 
  • Shoulder arthroscopy and open procedures 
  • Treatment of osteochondral defects 
  • Vertebroplasty/Kyphoplasty 

Interventional pain management services


Precertification is performed by Carelon Medical Benefits Management, an independent company.  For additional information, refer to the current version of Medical Policy #00.01.66: Musculoskeletal Services..  

  • Epidural Injection Procedures and Diagnostic Selective Nerve Root Blocks 
  • Paravertebral Facet Injection/Nerve Block/Neurolysis 
  • Regional Sympathetic Nerve Block 
  • Sacroiliac joint injections 
  • Implanted spinal cord stimulators 

Reconstructive procedures and potentially cosmetic procedures​​ 


  • Blepharoplasty/ptosis repair

    15820, 15821, 15822, 15823, 67900, 67901, 67902, 67903, 67904, 67906, 67908, 67909​
     
  • Bone graft, genioplasty and mentoplasty

    21120, 21121, 21122, 21123
     
  • Breast Reconstruction

    11920, 11921, 11922, 11970, 11971, 15271, 15272, 15769, 15771, 15772, 15773, 15774, 15777, 19300, 19350, 19355, 19357, 19361, 19364, 19367, 19368, 19369, 19380, Q4100, Q4107, Q4116, Q4130, Q4142, Q4143, S2066, S2067, S2068
     
  • Breast Reduction

    15877, 19318
     
  • Breast Augmentation/Mammoplasty

    19325
     
  • Breast Mastopexy

    19316
     
  • Insertion of Breast Implants

    19340, 19342, 19396
     
  • Removal of Breast Implants

    19328, 19330, 19370, 19371
     
  • Canthopexy/Canthoplasty

    21280, 21282, 67950
  • Cervicoplasty

    17999​

  • Chemical peels

    15788, 15789, 15792, 15793​
​
  • Dermabrasion

    15780, 15781, 15782, 15783
     
  • Excision of excessive skin and/or subcutaneous tissue

    15830, 15832, 15833, 15834, 15835, 15836, 15837, 15838, 15839
     
  • Gender Affirming interventions 

    11920, 11921, 11922, 11960, 15877, 17380, 19303, 53430, 54125, 54400, 54401, 54405, 54520, 54660, 54690, 55175, 55180, 57106, 57110, 58150, 58180, 58260, 58262, 58275, 58290, 58291, 58541, 58542, 58543, 58544, 58550, 58552, 58553, 58554, 58570, 58571, 58572, 58573, 58720

     
  • Genetically and bio-engineered skin substitutes for wound care​

​​​​​​
​​​​​​A2001, A2002, A2004, A2007, A2008, A2009, A2010, A2011, A2012, A2013, A2014, A2015, A2016, A2018, A2019, A2021, ​​​A2022, A2023, A2024, A2025, A2026, A2027, A2028, Q4100, Q4101, Q4102, Q4103, Q4104, Q4105, Q4106, Q4107, Q4108, ​Q4110, Q4111, Q4113, Q4114, Q4115, Q4117, Q4118, Q4121, Q4122, Q4123, ​Q​4124, Q4126, Q4127, Q4128, Q4132, Q4133, ​Q4134, Q4135, Q4136, Q4137,​ Q4139, Q4140, Q4141, Q4145, Q4146, Q4147, Q4148, Q4149, Q4151, Q4152, Q4153, Q4154, Q4155, Q4156, Q4157, Q4158, Q4159, Q4160, Q4161, Q4162, Q4163, Q4164, Q4165, Q4166, Q4167, Q4168, Q4169, Q4170, Q4171, Q4173, Q4174, Q4175, Q4176, Q4177, Q4178, Q4179, Q4180, Q4181, Q4182, Q4199, ​Q4205, Q4206, Q4208, Q4209, Q4211, Q4214, Q4215, Q4216, Q4217, Q4218, Q4219, Q4220, Q4221, Q4222, Q4224, Q4225, Q4227, Q4228, Q4229, Q4230, Q4231, Q4232, Q4233, Q4234, Q4235, Q4236, Q4237, Q4238, Q4239, Q4245, Q4246, Q4247, Q4248, Q4249, Q4250, Q4251, Q4252, Q4253, Q4254, Q4255, Q4256, Q4257, Q4258, Q4259, Q4260, Q4261, ​Q4262, Q4263, Q4264, Q4265, Q4266, Q4267, Q4268, Q4269, Q4270,​ Q4271, Q4272, Q4273, Q4274, Q4275, Q4276, Q4278, Q4279, Q4280, Q4281, Q4282, Q4283, Q4284, Q4287, Q4288, Q4289, Q4290, Q4291, Q4292, Q4293, Q4294, Q4295, Q4296, Q4297, Q4298, Q4299, Q4300, Q4301, Q4302, Q4303, Q4304, Q4305, Q4306, Q4307, Q4308, Q4309, Q4310, Q4311, Q4312, Q4314, Q4317, Q4318, Q4319, Q4320, Q4321, Q4322, Q4325, Q4326, Q4327, Q4328, Q4329, Q4330, Q4331, Q4332, Q4333, Q4336, Q4337, Q4338, Q4339, Q4340, Q4341, Q4342, Q4344, Q4345


​
  • Hair transplant

    15775, 15776
     
  • Keloid removal

    13100, 13101, 13102, 13120, 13121, 13122, 13131, 13132, 13133, 13151, 13152, 13153, 14000, 14001, 14020, 14021, 14040, 14041, 14060, 14061, 14301, 14302, 15002, 15003, 15004, 15005, 15040, 15050, 15100, 15101, 15110, 15111, 15115, 15116, 15120, 15121, 15130, 15131, 15135, 15136, 15150, 15151, 15152, 15155, 15156, 15157, 15200, 15201, 15220, 15221, 15240, 15241, 15260, 15261, 15271, 15272, 15273, 15274, 15275, 15276, 15277, 15278, 15570, 15572, 15574, 15576, 15600, 15610, 15620, 15630, 15650, 15731, 15733, 15734, 15736, 15738, 15740, 15750, 15756, 15757, 15758, 15760, 15770, 15780, 15781, 15782, 15783, 15786, 15787, 31830
     
  • Lipectomy, liposuction, or any other excess fat-removal procedure

    15832, 15833, 15834, 15835, 15836, 15837, 15838, 15839, 15876, 15877, 15878, 15879
     
  • Otoplasty

    13151, 13152, 13153, 14060, 14061, 15260, 15261, 21235, 69300, 69399
     
  • Rhinoplasty

    30400, 30410, 30420, 30430, 30435, 30450
     
  • Rhytidectomy

    15824, 15825, 15826, 15828, 15829, 15838, 15839, 15876
     
  • Scar revision

    13100, 13101, 13102, 13120, 13121, 13122, 13131, 13132, 13133, 13151, 13152, 13153, 14000, 14001, 14020, 14021, 14040, 14041, 14060, 14061, 14301, 14302, 15002, 15003, 15004, 15005, 15040, 15050, 15100, 15101, 15110, 15111, 15115, 15116, 15120, 15121, 15130, 15131, 15135, 15136, 15150, 15151, 15152, 15155, 15156, 15157, 15200, 15201, 15220, 15221, 15240, 15241, 15260, 15261, 15271, 15272, 15273, 15274, 15275, 15276, 15277, 15278, 15570, 15572, 15574, 15576, 15600, 15610, 15620, 15630, 15650, 15731, 15733, 15734, 15736, 15738, 15740, 15750, 15756, 15757, 15758, 15760, 15770, 15780, 15781, 15782, 15783, 15786, 15787, 31830
     
  • Skin closures

    13100, 13101, 13102, 13120, 13121, 13122, 13131, 13132, 13133, 13151, 13152, 13153, 14000, 14001, 14020, 14021, 14040, 14041, 14060, 14061, 14301, 14302, 15002, 15003, 15004, 15005, 15040, 15050, 15100, 15101, 15110, 15111, 15115, 15116, 15120, 15121, 15130, 15131, 15135, 15136, 15150, 15151, 15152, 15155, 15156, 15157, 15200, 15201, 15220, 15221, 15240, 15241, 15260, 15261, 15271, 15272, 15273, 15274, 15275, 15276, 15277, 15278, 15570, 15572, 15574, 15576, 15600, 15610, 15620, 15630, 15650, 15731, 15733, 15734, 15736, 15738, 15740, 15750, 15756, 15757, 15758, 15760, 15770
     
  • Surgery for varicose veins, including perforators and sclerotherapy

    36465, 36466, 36470, 36471, 36475, 36476, 36478, 36479, 37500, 37700, 37718, 37722, 37735, 37760, 37761, 37765, 37766, 37780, 37785, 37799 ​

Elective (nonemergency) ground, air, and sea ambulance transportation


A0140, A0426, A0428, A0430, A0431, A0434, S9960, S9961 

Outpatient private-duty nursing


S9123, S9124 

Day rehabilitation programs


0931, 0932 

Outpatient radiation therapy


Precertification review is provided by CareCore National, LLC d/b/a eviCore healthcare (eviCore). 

Radiology


Precertification is performed by Carelon Medical Benefits Management, an independent company. 

  • CT 
  • CTA 
  • Echocardiography services
    • Testing transthoracic echocardiography (TTE) 
    • Stress echocardiography (SE) 
    • Transesophageal echocardiography (TE)
  • MRA 
  • MRI 
  • Nuclear cardiology 
  • PET scans

Prosthetics/orthoses including: 


  • Custom ankle-foot orthoses

    L1900, L1904, L1907, L1920, L1940, L1945, L1950, L1960, L1970, L1980, L1990, L2106, L2108, L4631
     
  • Custom knee-ankle-foot orthoses

    L2000, L2005, L2010, L2020, L2030, L2034, L2036, L2037, L2038, L2126, L2128
     
  • Custom knee braces

    L1834, L1840, L1844, L1846, L1860
     
  • Custom limb prosthetics including accessories/components

    • L5010, L5020, L5050, L5060, L5100, L5105, L5150, L5160, L5200, L5210, L5220, L5230, L5250, L5270, L5280, L5301, L5312, L5321, L5331, L5341, L5510, L5520, L5530, L5535, L5540, L5560, L5570, L5580, L5585, L5590, L5595, L5600, L5610, L5611, L5613, L5614, L5615, L5616, L5617, L5618, L5620, L5622, L5624, L5626, L5628, L5629, L5630, L5631, L5632, L5634, L5636, L5637, L5638, L5639, L5640, L5642, L5643, L5644, L5645, L5646, L5647, L5648, L5649, L5650, L5651, L5652, L5653, L5654, L5655, L5656, L5658, L5661, L5665, L5666, L5668, L5670, L5671, L5672, L5673, L5676, L5677, L5678, L5679, L5680, L5681, L5682, L5683, L5684, L5685, L5686, L5688, L5690, L5692, L5694, L5695, L5696, L5697, L5698, L5699, L5700, L5701, L5702, L5703, L5704, L5705, L5706, L5707, L5710, L5711, L5712, L5714, L5716, L5718, L5722, L5724, L5726, L5728, L5780, L5781, L5782, L5783, L5785, L5790, L5795, L5810, L5811, L5812, L5814, L5816, L5818, L5822, L5824, L5826, L5828, L5830, L5840, L5841, L5845, L5848, L5850, L5855, L5856, L5857, L5858, L5859, L5910, L5920, L5925, L5926, L5930, L5940, L5950, L5960, L5962, L5964, L5966, L5968, L5970, L5971, L5972, L5973, L5974, L5975, L5976, L5978, L5979, L5980, L5981, L5982, L5984, L5985, L5986, L5987, L5988, L5990, L5999, L6000, L6010, L6020, L6050, L6055, L6100, L6110, L6120, L6130, L6320, L6350, L6360, L6370, L6400, L6450, L6500, L6550, L6570, L6580, L6582, L6584, L6586, L6588, L6590, L6600, L6605, L6610, L6611, L6615, L6616, L6620, L6621, L6623, L6624, L6625, L6628, L6629, L6630, L6632, L6635, L6637, L6638, L6640, L6641, L6642, L6645, L6646, L6647, L6648, L6650, L6655, L6660, L6665, L6670, L6672, L6675, L6676, L6677, L6680, L6682, L6684, L6686, L6687, L6688, L6689, L6690, L6691, L6692, L6693, L6694, L6695, L6696, L6697, L6698, L6703, L6704, L6706, L6707, L6708, L6709, L6711, L6712, L6713, L6714, L6715, L6721, L6722, L6805, L6810, L6880, L6881, L6882, L6883, L6884, L6885, L6890, L6895, L6900, L6905, L6910, L6915, L6920, L6925, L6930, L6935, L6940, L6945, L6950, L6955, L6960, L6965, L6970, L6975, L7007, L7008, L7009, L7040, L7045, L7170, L7180, L7181, L7185, L7186, L7190, L7191, L7260, L7400, L7401, L7402, L7403, L7404, L7405, L7499​

 Selected durable medical equipment (DME) 

  • Bone growth stimulators

    E0747, E0760
     
  • Bone growth stimulator, electrical, noninvasive, spinal

    Precertification is performed by Carelon Medical Benefits Management, an independent company.  For additional information, refer to the current version of Medical Policy #00.01.66: Musculoskeletal Services.
     
  • Bone-anchored (osseointegrated) hearing aids

    69716, 69719, 69726, 69727, L8690, L8691, L8692, L8693, L8694
     
  • Continuous positive airway pressure (CPAP) devices, bi-level (Bi-PAP) devices, and all supplies

    Precertification is performed by Carelon Medical Benefits Management, an independent company.
     
  • Dynamic adjustable and static progressive stretching devices (excludes CPMs)

    E1800, E1802, E1805, E1810, E1812, E1825, E1830
     
  • Electric, power, and motorized wheelchairs including custom accessories

    E1002, E1003, E1004, E1005, E1006, E1007, E1008, E1009, E1010, E1012, E1239, E2291, E2292, E2293, E2294 E2310, E2311, E2312, E2313, E2321, E2322, E2323, E2324, E2325, E2326, E2327, E2328, E2329, E2330, E2331 E2340, E2341, E2342, E2343, E2351, E2368, E2369, E2370, E2373, E2374, E2375, E2376, E2377, E2603, E2604, E2605, E2606, E2607, E2608, E2609, E2613 E2614, E2615, E2616, E2617, E2620, E2621, E2622, E2623, E2624, E2625, E2626, E2627, E2628, E2629, E2630, K0010, K0011, K0012, K0013, K0014, K0056, K0108, K0813, K0814, K0815, K0816, K0820, K0821, K0822, K0823, K0824, K0825, K0826, K0827, K0828, K0829, K0835, K0836, K0837, K0838, K0839, K0840, K0841, K0842, K0843 K0848, K0849, K0850, K0851, K0852, K0853, K0854, K0855, K0856, K0857, K0858, K0859, K0860, K0861, K0862 K0863, K0864, K0890, K0891, K0898
     
  • Insulin pumps

    E0784, E0787, S1034
     
  • Manual wheelchairs with the exception of those that are rented

    E0958, E1002, E1003, E1004, E1005, E1006, E1007, E1008, E1009, E1010, E1012, E1031, E1037, E1038, E1039 E1050, E1060, E1070, E1083, E1084, E1085, E1086, E1087, E1088, E1089, E1090, E1092, E1093, E1100, E1110  E1130, E1140, E1150, E1160, E1161, E1170, E1171, E1172, E1180, E1190, E1195, E1200, E1220, E1221, E1222  E1223, E1224, E1229, E1231, E1232, E1233, E1234, E1235, E1236, E1237, E1238, E1240, E1250, E1260, E1270  E1280, E1285, E1290, E1295, E2291, E2292, E2293, E2294, E2295, E2603, E2604, E2605, E2606, E2607, E2608  E2609, E2613, E2614, E2615, E2616, E2617, E2620, E2621, E2622, E2623, E2624, E2625, E2626, E2627, E2628  E2629, E2630, K0001, K0002, K0003, K0004, K0005, K0006, K0007, K0008, K0009, K0108
     
  • Negative pressure wound therapy

    A6550, A9272, E2402, K0743, K0744, K0745, K0746
     
  • Neuromuscular stimulators

    E0744, E0745, E0764, E0770
     
  • Power operated vehicles (POV)

    E1230, K0800, K0801, K0802, K0812
     
  • Pressure reducing support surfaces including: 
    • Air fluidized bed

      E0194
       
    • Non powered advanced pressure reducing mattress

      E0371, E0373
       
    • Powered air flotation bed (low air loss therapy)

      E0193, E0372
       
    • ​Powered pressure reducing mattress

      E0277 
  • Push rim activated power assist devices

    E0986
     
  • Repair or replacement of all DME items, as well as orthoses and prosthetics that require precertification - See specific DME, orthoses, and prosthetics categories for Repair or Replacement codes that require precertification.

     
  • ​Speech generating devices
    E2500, E2502, E2504, E2506, E2508, E2510, E2511, E2599, V5336

Medical foods


B4149, B4150, B4152, B4153, B4154, B4155, B4157, B4158, B4159, B4160, B4161, B4162, S9433, S9434, S9435

Hyperbaric oxygen therapy


0413, G0277 

In-Lab / Facility sleep studies


Precertification is performed by Carelon Medical Benefits Management, an independent company.

Proton beam therapy


Precertification review is provided by CareCore National, LLC d/b/a eviCore healthcare (eviCore).


All transplant procedures, with the exception of corneal transplants


0584T, 0585T, 0586T, 15775, 15776, 27415, 27416, 29866, 29867, 32851, 32852, 32853, 32854, 33935, 33945, 38205, 38206, 38207, 38208, 38209, 38210, 38211, 38212, 38213, 38214, 38215, 38230, 38232, 38240, 38241, 38242, 38243, 44133, 44135, 44136, 44137, 47135, 47140, 47141, 47142, 47399, 48160, 48554, 48556, 50320, 50340, 50360, 50365, 50370, 50380, 50547, G0341, G0342, G0343, S2053, S2054, S2060, S2061, S2065, S2103, S2140, S2142, S2150
 

Mental health/serious mental illness/substance abuse


 
  • Mental health and serious mental illness treatment (inpatient/partial hospitalization programs/intensive outpatient programs) 
  • Repetitive transcranial magnetic stimulation (RTMS) 
  • Substance abuse treatment (inpatient/partial hospitalization programs/intensive outpatient programs)
 

Autism spectrum disorders 


  • Applied behavioral analysis


Genetic and genomic tests requiring precertification


Precertification review is provided by CareCore National, LLC d/b/a eviCore healthcare (eviCore).

The following list is a guide to the types of genetic and genomic tests that require precertification. Due to the volume of tests, it is not possible to list each test separately. To determine if a test requires precertification, please see the complete procedure code list for details. Please note: precertification of genetic and genomic tests applies to commercial members only. 

Hereditary cancer syndromes 


  • BRCA gene testing (breast and ovarian cancer syndrome) 
  • Lynch syndrome gene testing 
  • Familial adenomatous polyposis gene testing 
  • PTEN gene testing (Cowden syndrome) 
  • General cancer type panels (such as colon, breast, or neuroendocrine cancers)​​ 

​Hereditary heart disease​s


  • Long QT syndrome gene testing 
  • ​Aortic dilation or aneurysm syndrome testing (includes Marfan syndrome) 

Other full gene analysis testing 


  • Cystic fibrosis full gene sequencing and deletion/duplication analysis 
  • ​PMP22 full gene sequencing and deletion/duplication analysis (Charcot-Marie-Tooth, hereditary neuropathy) 

Tests for many genetic disorders simulta​​​neously 


  • Expanded carrier screening panels (such as Carrier Status DNA Insight®, Counsyl Family Prep Screen, Pan-Ethnic Carrier Screening) 
  • Hearing loss panels 
  • Intellectual disability panels 
  • Noonan spectrum disorders panels
 
Specialty oncology tests 
  • Cancer gene expression or protein signature tests (such as OncotypeDX®, MammaPrint®, Afirma®, Prosigna®, HeproDX™) 
  • Tumor molecular profiling (such as FoundationOne®, neoTYPE™, OncoPlexDx®, and many others) 
  • Tissue of origin testing (for cancer of unknown primary) 
  • ​​PCA3 testing for prostate cancer

Pharmacogenomic tests 


  • Cytochrome P450 metabolism gene testing (CYP2D6, CYP2C9, CYP2C19) 
  • Specialized drug response gene panels (such as Assurex GeneSight®, GeneTrait, Genecept®, Millennium PGTSM) 
  • Warfarin response testing 
  • MGMT methylation analysis for glioblastoma 

Other spec​​ialty tests 


  • Coronary artery disease risk testing (such as CorusCAD®, CardioIQ®, APOE, ACE, KIF6) 
  • ​Heart disease risk testing (such as CorusCAD®, CardioIQ®, APOE, ACE, KIF6, MTHFR) 

Genome-wide te​​​​​​sts 


  • Microarray studies 
  • Whole exome testing 
  • Whole genome testing 
  • ​Mitochondrial genome or nuclear testing 

ANY genetic test for more than one gene or condition (often includes words like “panel" or “comprehensive" in the nam​e) 


ANY genetic test th​at will be billed with a non-specific procedure code 


  • Billed with CPT® codes 81400-81408 
  • ​Billed with an unlisted code: 81479, 81599, 84999

Specialty drugs requi​​​ring precert​​ification


All listed brands and their generic equivalents or biosimilars require precertification. This list is subject to change. 

Amyotrophic Lateral Sclerosis agents​​​

  • NurOwn® - J3490, J3590, and C9399​


Antineoplastic agen​​ts

  • Abraxane® - J9264
  • Adstiladrin® - J9029​
  • Adcetris® - J9042
  • Anktiva® - J9028
  • Alymsys® - Q5126 (Note: Ophthalmologic use of Alymsys does not require precertification.)
  • Avastin® - C9257, J9035, and Q5129 (Note: Ophthalmologic use of Avastin does not require precertification. Precertification requirements apply to all FDA-approved biosimilars to this reference product.)
  • ​Avzivi® - J3490, J3590, and C9399​
  • Azedra - A9590
  • Blincyto™ - J9039
  • Columvi™ - J9286​
  • Cyramza® - J9308
  • Darzalex™ - J9145
  • Darzalex Faspro™ – J9144
  • Elahere™ - J9063
  • Elrexfio™ - J1323
  • Enhertu® - J9358
  • ​Epkinly™ - J9321​
  • Erbitux® - J9055
  • Herceptin® -J9355(Precertification requirements apply to all FDA-approved biosimilars to this originator product.)
  • Herceptin® Hylecta - J9356
  • Herzuma® - Q5113
  • Imjudo® - J9347
  • Kadcyla® - J9354
  • Kimmtrak® - J9274
  • Kyprolis® - J9047
  • Loqtorzi™ - J3263​
  • Lunsumio™ - J9350
  • Margenza™ - J9353
  • Monjuvi® - J9349
  • Ogivri™ - Q5114
  • Ontruzant®- Q5112
  • Opdualag™ - J9298
  • Padcev™-J9177
  • ​Patritumab Deruxtecan - J3490, J3590, and C9399​
  • Pemfexy™ - J9304​
  • Perjeta® - J9306
  • Phesgo™ - J9316
  • Pluvicto™* - J3490 and C9399​
  • Polivy™ - J9309
  • Poteligeo® - J9204
  • Provenge® - Q2043
  • Riabni™ - J3490, J3590, and C9399
  • Rituxan® - J9312 (Precertification requirements apply to all FDA-approved biosimilars to this originator product.)
  • Rituxan Hycela™ - J9311
  • Rybrevant™ - J9061 
  • Rylaze™ - J9021​
  • ​Rytelo™ - J0870​
  • Sarclisa® - J9227
  • Taclantis (pending FDA approval) - J3490 and C9399
  • Talvey™ - ​J3055
  • Tecvayli™ - J9380​
  • Tivdak™ - J9273
  • Trodelvy® - J9317
  • Xofigo®* - A9606
  • Yervoy™ - J9228
  • Zepzelca™ – J9223
  • Zevalin®* - A9543
  • Zolbetuximab (pending FDA approval) - J3490, J3590, and C9399​
  • Zynlonta™ J9359

* Precertification review is provided by CareCore National, LLC d/b/a eviCore healthcare (eviCore).
​​
​​ Anti PD-1/PD-L1 human monoclonal antibodies

All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year. 
  • Bavencio® - J9023
  • ​Camrelizumab (pending FDA approval) - J3490, J3590, and C9399
  • Cosentyx® IV – J3247​
  • Cosibelimab (pending FDA approval) - J3490, J3590, and C9399​
  • Imfinzi™ - J9173
  • Jemperli™ - J9272
  • Keytruda™ - J9271
  • Libtayo® - J9119
  • Opdivo® - J9299
  • Opdivo Qvantig™ - J3590 and C9399​
  • Penpulimab (pending FDA approval) - J3490, J3590, and C9399​​
  • ​Tecentriq™ - J9022
  • ​Tecentriq Hybreza™ - J3590, J9999, and C9399​
  • Tevimbra® - J9329
  • Zynyz™ - J9345​

​​​​Bone-modifying agents


  • Evenity™ - J3111
  • Jubbonti® - Q5136
  • Prolia® - J0897
  • Wyost® - Q5136
  • Xgeva® - J0897
    •  

Botulinum toxin agen​​ts 


  • ​Botox® -J0585 

Chimeric antigen recept​​or (CAR-T) therapies


All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year. 
  • Abecma® - Q2055
  • Breyanzi® - Q2054
  • Carvykti™ - Q2056
  • Kymriah™ - Q2042
  • Obecabtagene autotemcel - J3490, J3590, and C9399​
  • Tecartus™ - Q2053
  • ​Yescarta™ - Q2041
  • Chimeric antigen receptor t-cell (car-t) therapy; car-t cell administration, autologous – 38228


Endocrine/metabolic agents


  • Acthar® Gel - J0801 and J0802​
  • Lanreotide - J1932
  • Lutathera®* - A9513 and A9699
  • Sandostatin® LAR - J2353
  • Somatuline® depot - J1930 
  • Xenpozyme™ - J0218​
​
* Precertification review is provided by CareCore National, LLC d/b/a eviCore healthcare (eviCore).
​​

Enzyme replacement agents


All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year.
  • Aldurazyme® - J1931
  • Adzynma - J7171​
  • Brineura™ - J0567
  • Cerezyme® - J1786
  • Cinaxadamtase Alfa (pending FDA approval) – J3490, J3590, and C9399​
  • ​Cipaglucosidase Alfa (pending FDA approval) – J3490, J3590, and C9399​
  • Elaprase® - J1743
  • Elelyso® - J3060
  • Elfabrio® - J2508​
  • Fabrazyme® -J0180
  • Kanuma® - J2840
  • Lamzede® - J0217​
  • Lumizyme® - J0221
  • Mepsevii™ - J3397
  • Naglazyme® - J1458
  • ​Nexviazyme™ - J0219
  • ​Pombiliti™ - J1203​
  • Replagal® (pending FDA approval) - J3490
  • Revcovi™ - J3590 and C9399
  • Vimizim™ - J1322​
  • Vpriv® - J3385​
  • Xenpozyme® - J3590 and C9399


​Gene Replacement / Gene Editing Therapies


All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year. 

  • ​Beqvez™ - J1414
  • Casgevy™ - J3392
  • Eladocagene exuparvovec - J3490, J3590, and C9399​
  • Elevidys® - J1413
  • ​Hemgenix® - J1411​
  • Lenmeldy™ - J3590 and C9399​
  • Luxturna™ - J3398
  • Lyfgenia™ - J3394
  • Marnetegragen​​e aututemcel - J3490, J3590, and C9399
  • ​​Prademagene zamikeracel - J3490, J3590, and C9399
  • Roctavian® - J1412​
  • Skysona® -J3590 and C9399​
  • Vvjuvek™ - J3401​
  • Zolgensma® - J3399
  • Zynteglo® - J3393

Hemophil​ia/Coagulation factors


All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year. 

  • Advate® - J7192
  • Adynovate® - J7207
  • Afstyla® - J7210
  • Alphanate® - J7186
  • Alphanine SD® - J7193
  • Alprolix® - J7201
  • Altuviiio™ - J7214
  • Bebulin VH® - J7194
  • Benefix® - J7195
  • Coagadex® - J7175
  • Corifact® - J7180
  • Eloctate® - J7205
  • Esperoct® - J7204
  • Feiba NF® - J7198
  • Feiba VH® - J7198
  • Fibryga® - J7177
  • Helixate FS® -J7192
  • Hemlibra® - J7170
  • Hemofil-M® - J7190
  • Humate-P® - J7187
  • Hympavzi™ - J3590 and C9399​
  • Idelvion® - J7202
  • Ixinity® - J7213
  • Jivi® - J7199 and J7208
  • Koate-DVI® - J7190
  • Kogenate FS® -J7192
  • Kovaltry® - J7207 and J7211
  • Monarc® - J7190
  • Mononine® - J7193
  • Novoeight® - J7182
  • Novoseven RT® -J7189
  • Novoseven® - J7189
  • Nuwiq® - J7209
  • Obizur® - J7188
  • Profilnine SD® - J7194
  • Rebinyn® - J7203
  • Recombinate® - J7192
  • RiaSTAP® - J7178
  • Rixubis® -J7195 and J7200
  • Sevenfact® - J7212
  • Tretten® - J7181
  • Vonvendi® - J7179 and J7199
  • Wilate® - J7183
  • ​Xyntha® - J7185 

Hyaluronate acid pro​​​ducts


  • Cingal (pending FDA approval) - J3490
  • Durolane® - J7318
  • Euflexxa™ -J7323
  • Gel-One® - J7326
  • Gelsyn-3™ - J7328
  • GenVisc 850® -J7320
  • Hyalgan® -J7321
  • Hymovis® - J7322
  • Supartz® -J7321
  • Synojoynt™ - J7331
  • Triluron™​ -J7332
  • TriVisc™ - J7329
  • ​VISCO-3® - J7321

Immunological a​​​​gents


  • Actemra®- J3262 (See note below.)
  • Benlysta® IV - J0490
  • Entyvio™ - J3380 (See note below.)
  • Ilumya™ - J3245
  • Omvoh™ - J2267
  • Orencia® IV - J0129
  • Pyzchiva® - Q9996 and Q9997
  • Saphnelo™ -J0491
  • Selarsdi™ - Q9998
  • Simponi® Aria - J1602
  • Skyrizi® IV - J2327
  • Spevigo® - J1747​
  • Stelara®- J3357 and J3358  
  • Tofidence™ - Q5133​​
  • Tremfya® IV - J1628
  • Tyenne® - Q5135​
  • Wezlana – Q5137, Q5138​

​​​​HCPCS codes J3362 and J3380 will only require precertification when not reported with the JB modifier.​

Intrave​​​nous Immune Globulin/Sub​​​cutaneous Immune Globulin (IVIG/SCIG)


All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year.
 
  • Intravenous Immune Globulin (IVIG)

    • Alyglo™ - J1552
    • Asceniv® - J1554
    • Bivigam® - J1556
    • Flebogamma® - J1572
    • Flebogamma-Dif® - J1572
    • Gammagard Liquid® - J1569
    • Gammagard S/D® -J1566
    • Gammaked® - J1561
    • Gammaplex® - J1557
    • Gamunex-C® - J1561
    • Octagam® - J1568
    • Panzyga® - J1576
    • Privigen® - J1459 
  • Subcutaneous Immune Globulin (SCIG)
    • Cutaquig® - J1551
    • Cuvitru® - J1555
    • Hizentra® - J1559
    • Hyqvia® - J1575
    • Xembi​​fy®​ - J1558

 Multiple sclero​sis a​​gents


All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year. 

  • ​Briumvi™ - J2329
  • Lemtrada® - J0202
  • Ocrevus™ - J2350
  • ​Tyruko® - Q5134​
  • Tysabri® - J2323 ​

 Myasthemia Gravis Agents


All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year.

  • Rystiggo® - J9333
  • Vyvgart™ - J9332
  • Vyygart® Hytrulo - J9334​


Neutropenia

​

  • Efbemalenograstim Alfa (pending FDA approval) - J3490, J3590, and C9399
  • Fulphila™ - Q5108
  • Fylnetra® - Q5130
  • ​Granix® - J1447​
  • Lapelga (pending FDA approval) - J3490, J3590, and C9399
  • Neupogen® - J1442
  • ​Nypozi® - J3590 and C9173​
  • Releuko™ - Q5125
  • Rolvedon™ - J1449
  • ​Ryzneuta® - J9361
  • Stimufend® - Q5127
  • Udenyca™ - Q5111
  • Ziextenzo® - Q5120​


Ophthalm​ic agents 

​

  • Ahzantive® - J3490, J3590, and C9399​
  • Beovu® - J0179
  • ​​Byooviz™ - Q5124
  • Cimerli™ - Q5128​
  • Enzeevu™ - J3490, J3590, and C9399​
  • Eylea® - J1078(Precertification requirements apply to all FDA-approved biosimilars to this reference product.)
  • ​Eylea® HD – J1077 (Precertification requirements apply to all FDA-approved biosimilars to this reference product.)
  • Lucentis® - J2778 ​(Precertification requirements apply to all FDA-approved biosimilars to this reference product.)​
  • Opuviz - J3490, J3590, and C9399
  • Pavblu™ - J3490, J3590, and C9399
  • ​Susvimo™- J2779
  • ​Tepe​zza® - J3241 
  • Vabysmo® ​- J2777
  • Yesafili™ - J3490, J3590, and C9399​


Pulmonary arterial h​​​​ypertension


All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year.
  • Flolan® - J1325
  • Remodulin® - J3285
  • Revatio® - J3490 and C9399
  • Tyvaso® - J7686
  • Veletri® - J1325
  • ​Ventavis® - Q4074 

Respirato​​ry agents​


  • Cinqair® - J2786
  • Synagis® - 90378
  • ​Xolair® - J2357 

Respiratory enzymes (Alpha-1 a​​ntitrypsin)


All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year. 

  • Aralast - J0256
  • Glassia™ - J0257
  • Prolastin® -J0256
  • ​Zemaira® - J0256 

Tumor Infiltrating Lymphocyte (TIL) Therapy


All drugs that can be classified under this header require precertification. This includes any unlisted brand or generic names, or biosimilars, as well as new drugs that are approved by the FDA in that class during the course of the benefit year.​

  • Amtagvi™ – J3590, and C9399​​
  • Imdelltra™- J9026
  • Linvoseltamab - J3490, J3590, and C9399
  • Tecelra® - J3490, J3590, and C9399

Miscellaneous therapeutic a​​gents 


  • Adakveo® - J0791
  • Ampligen® (pending FDA approval) - J3490
  • Amvuttra™ - J0225​
  • ​Bkemv™ - Q5139​
  • Cosela® - J1448
  • Crysvita® - J0584
  • Enjaymo™ - J1302
  • Epysqli® - J3490, J3590, and C9399​
  • Evkeeza™ - J1305
  • Exenatide sustained-release ITCA 650 (pending FDA approval) - J3490
  • Gamifant® - J9210
  • Givlaari® - J0223
  • Ilaris® - J0638
  • Injectafar® - J1439​
  • Krystexxa®​ - J2507
  • ​​Lantidra® - J3490, J3590, and C9399​
  • Leqvio® - J1306​
  • Monoferric® - J1437​
  • Narsoplimab (pending FDA approval) - C9399 and J3590​
  • ​Niktimvo™ - J3490, J3590, and C9399​
  • Onpattro® - J0222
  • Oxlumo™ - J0224​
  • PiaSky® - J1307​
  • Reblozyl® - J0896
  • Remune (pending FDA approval) - J3490
  • Rethymic™ - J3590 and C9399
  • Soliris® - J1300(Precertification requirements apply to all FDA-approved biosimilars to this originator product.)
  • Spinraza™ -J2326
  • ​Tzield™ - J9381​
  • Ultomiris™ - J1303
  • Uplizna - J1823
  • Veopoz™ - J9376​
  • ​Vyepti™ - J3032
  • ​Xiaflex® - J0775
​

Revisio​ns​

​

January 1, 2025

 
The following revisions were incorporated into the January 1, 2025 update.​

Additions​

Reconstructive procedures and potentially cosmetic procedures

Cervicoplasty 17999

Antineoplastic agents

Anktiva® - J9028
Avzivi® - J3490, J3590, and C9399
Patritumab deruxtecan - J3490, J3590, and C9399
Rytelo™ - J0870

Anti PD-1/PD-L1 human monoclonal antibodies

Opdivo Qvantig™ - J3590 and C9399
Tecentriq Hybreza™ - J3590, J9999, and C9399

Chimeric antigen receptor (CAR-T) therapies

Obecabtagene autotemcel - J3490, J3590, and C9399
Chimeric antigen receptor t-cell (car-t) therapy; car-t cell administration, autologous - 38228

Gene Replacement / Gene Editing Therapies

Beqvez™ - J1414
Casgevy™ - J3392
Eladocagene exuparvovec - J3490, J3590, and C9399​

Lyfgenia™ - J3394​​​

Marnetegragene aututemcel - J3490, J3590, and C9399
Prademagene zamikeracel - J3490, J3590, and C9399

Zynteglo® - J3393

Hemophilia/Coagulation factors

Hympavzi™ - J3590 and C9399

Immunological agents

Pyzchiva® - Q9996 and Q9997
Selarsdi™ - Q9998
Tremfya® IV - J1628

Intravenous Immune Globulin/Subcutaneous Immune Globulin (IVIG/SCIG)

Alyglo™ - J1552

Neutropenia

Nypozi® - J3590 and C9173

Ophthalmic agents

Ahzantive® - J3490, J3590, and C9399
Enzeevu™ - J3490, J3590, and C9399
Opuviz - J3490, J3590, and C9399
Pavblu™ - J3490, J3590, and C9399
Yesafili™ - J3490, J3590, and C9399

Tumor Infiltrating Lymphocyte (TIL) Therapy

Imdelltra™- J9026
Linvoseltamab - J3490, J3590, and C9399
Tecelra® - J3490, J3590, and C9399

Miscellaneous therapeutic agents

Bkemv™ - Q5139
Epysqli® - J3490, J3590, and C9399
Injectafar® - J1439
Monoferric® - J1437
Niktimvo™ - J3490, J3590, and C9399

PiaSky® - J1307​

_______________________________________________________________________


Deletions

The following language was removed:

Any procedure, device, or service that may potentially be considered experimental or investigational including:

  • ​New emerging technology/procedures, as well as existing technology and procedures applied for new uses and treatments

Reconstructive procedures and potentially cosmetic procedures

Cervicoplasty 15819

Antineoplastic agents

Abraxane® - J9264
Anktiva® - J3490, J3590, and C9169
Erwinaze® - J9019
Imdelltra™ - J3490, J3590, and C9170

Chimeric antigen receptor (CAR-T) therapies

Chimeric antigen receptor t-cell (car-t) therapy; car-t cell administration, autologous – 0540T

Gene Replacement / Gene Editing Therapies

Beqvez™ - J3490, J3590, and C9172
Casgevy™ - J3490, J3590, and C9399

Lyfgenia™ - J3490, J3590, and C9399

Zynteglo® - J3590 and C9399

Intravenous Immune Globulin/Subcutaneous Immune Globulin (IVIG/SCIG)

Alyglo™ - J1599​

​

​CPT Copyright 2025​​ American Medical Association. All rights reserved. CPT® is a registered trademark of the American Medical Association.  

Independence Blue Cross offers products through its subsidiaries Independence Hospital Indemnity Plan, Keystone Health Plan East and QCC Insurance Company, and with Highmark Blue Shield — independent licensees of the Blue Cross and Blue Shield Association.
Connect with Us

2025 Independence Blue Cross

Independence Blue Cross is a subsidiary of Independence Health Group, Inc. — independent licensees of the Blue Cross and Blue Shield Association, serving the health insurance needs of Philadelphia and southeastern Pennsylvania.