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Upper Gastrointestinal Endoscopy (Diagnostic and Therapeutic)
MA07.023m

Policy

This policy uses coverage criteria developed solely based on applicable Medicare statutes, regulations, NCDs, LCDs, CMS manuals and other applicable Medicare coverage documents.


The Company reserves the right to reimburse only those services that are furnished in the most appropriate and cost-effective setting that is appropriate to the member’s medical needs and condition.​


ESOPHAGOGASTRODUODENOSCOPY (EGD)

MEDICALLY NECESSARY
Diagnostic EGD

An EGD is considered medically necessary and, therefore, covered for any of the following:
  • Upper abdominal distress (pain or discomfort) that persists despite an appropriate trial of therapy (e.g., acid suppression with proton-pump inhibitors [PPIs])
  • Upper abdominal distress (pain or discomfort) associated with symptoms and/or signs suggesting serious organic disease (e.g., prolonged anorexia and weight loss)
  • Dysphagia (difficulty or discomfort in swallowing) or odynophagia (painful swallowing)
  • Esophageal reflux symptoms that are persistent or recurrent despite appropriate therapy
  • Persistent vomiting of unknown cause
  • Other systemic diseases in which the presence of upper gastrointestinal (GI) pathology might modify other planned management (e.g., individuals with a history of GI bleeding who are scheduled for organ transplantation, long-term anticoagulation, and chronic nonsteroidal therapy for arthritis; Barrett esophagus)
  • X-ray findings for any of the following:
    • A suspected neoplastic lesion, for confirmation and specific histologic diagnosis
    • Gastric or esophageal ulcer
    • Evidence of upper GI tract stricture or obstruction
  • The presence of GI bleeding for any of the following:
    • In individuals actively bleeding or those recently stopped
    • When surgical therapy is contemplated
    • When re-bleeding occurs after acute self-limited blood loss or after endoscopic therapy
    • When portal hypertension or aortoenteric fistula is suspected
    • For presumed chronic blood loss and for iron deficiency anemia when a colonoscopy is negative
  • When sampling of duodenal or jejunal tissue or fluid is indicated
  • To assess acute injury after caustic agent ingestion
  • Intraoperatively to clarify a location or pathology of a lesion

Therapeutic EGD

A therapeutic EGD is considered medically necessary and, therefore, covered for any of the following indications:
  • Treatment of bleeding lesions, such as ulcers, tumors, vascular malformations (e.g., electrocoagulation, heater probe, laser photocoagulation or injection therapy)
  • Sclerotherapy treatment of bleeding from esophageal or proximal gastric varices or banding of varices

  • Removal of a foreign body
  • Removal of selected polypoid lesions
  • Placement of feeding tubes (oral, percutaneous endoscopic gastrostomy, percutaneous endoscopic jejunostomy)
  • Dilation of stenotic lesions (e.g., with transendoscopic balloon dilators or dilating systems using guidewires)
  • Palliative therapy for stenosing neoplasms (e.g., laser, bipolar electrocoagulation, stent placement)
NOT MEDICALLY NECESSARY
All other indications for EGD, such as but not limited to the following, are considered not medically necessary and, therefore, not covered:
  • Gastric distress that is chronic, nonprogressive, atypical for known organic disease, and considered functional in origin (there are occasional exceptions in which an endoscopic examination may be necessary once to rule out organic disease, especially if symptoms are unresponsive to therapy)
  • Uncomplicated heartburn responsive to medical therapy
  • Metastatic adenocarcinoma of unknown primary site when the results will not alter management
  • X-ray findings of:
    • Asymptomatic or uncomplicated sliding hiatus hernia
    • Uncomplicated duodenal bulb ulcer that has responded to therapy, or
    • Deformed duodenal bulb when symptoms are absent or respond adequately to ulcer therapy
  • Routine screening of the upper GI tract
  • Without current GI symptoms about to undergo elective surgery for non-upper GI disease​ 

  • When a lower GI endoscopy reveals the cause of symptoms, abnormal signs or laboratory tests (e.g., colonic neoplasm with iron deficiency anemia). Exceptions can be considered if medical necessity for this procedure can be demonstrated.
  • Sequential or periodic diagnostic EGD for the following:
    • Surveillance for malignancy in individuals with gastric atrophy, pernicious anemia, treated achalasia, or prior gastric operation
    • Surveillance of healed benign disease such as esophagitis, gastric or duodenal ulcer
    • Surveillance during chronic repeated dilations of benign strictures unless there is a change in status
ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP)​

MEDICALLY NECESSARY
Endoscopic retrograde cholangiopancreatography (ERCP) is considered medically necessary and, therefore, covered for any of the following indications:
  • For individuals with traumatic pancreatitis to accurately localize the injury and provide endoscopic drainage
  • For pancreatic duct stricture evaluation
  • For the extraction of bile duct stones in severe gallstone-induced pancreatitis
  • For the detection of pancreatic ductal changes in chronic pancreatitis and also the presence of calcified stones in the ductal system. A pancreatogram may be performed and is likely to be abnormal in chronic alcoholic pancreatitis, but less so in nonalcoholic-induced types.
  • For detecting gallstones in symptomatic individuals whose oral cholecystogram and gallbladder ultrasonograms are normal
  • For individuals with radiologic imaging that is suggestive of common bile duct stones or other potential pathology

An ERCP is typically not indicated for the following conditions:

  • For the diagnosis of pancreatitis except for suspected gallstone pancreatitis
  • For use in early stages or in acute pancreatitis, because of the possibility of exacerbation
EXPERIMENTAL/INVESTIGATIONAL
ERCP with ​confocal laser endomicroscopy to evaluate the pancreas and bile duct system is considered experimental/investigational and, therefore, not covered because the safety and effectiveness of these procedures cannot be established by review of the available published peer-reviewed literature.

REQUIRED DOCUMENTATION

The individual's medical record must reflect the medical necessity for the care provided. These medical records may include, but are not limited to: records from the professional provider's office, hospital, nursing home, home health agencies, therapies, and test reports.

The Company may conduct reviews and audits of services to our members, regardless of the participation status of the provider. All documentation is to be available to the Company upon request. Failure to produce the requested information may result in a denial for the service.

Guidelines

SEQUENTIAL OR PERIODIC DIAGNOSTIC UPPER ENDOSCOPIES MAY BE INDICATED FOR THE FOLLOWING:

Sequential or periodic upper gastrointestinal (GI) endoscopy may be indicated for an appropriate number of procedures for active or symptomatic conditions such as:

  • Selected esophageal, gastric or Misspelled Wordstomal ulcers to demonstrate healing
    • frequency of follow-up esophagogastroduodenoscopies (EGDs) is variable, but every 2 to 4 Misspelled WordmoMisspelled Wordnths until healing is demonstrated is reasonable
  •  Individuals with prior adenomatous gastric polyps
    • approximate frequency for follow-up EGDs would be 1 to 4 years depending on the clinical circumstances, with occasional individuals with sessile polyps requiring every-6-month surveillance initially
  • Adequacy of prior Misspelled Wordsclerotherapy or bonding of esophageal varices
    • approximate frequency of follow-up EGD is variable depending on the state of the individual, but every 6 to 24 months is reasonable after the initial Misspelled Wordsclerotherapy/banding sessions are completed
  • Barrett esophagus
    • approximate frequency of follow-up EGDs is 1 to 2 years with biopsies, unless dysplasia or atypia is demonstrated, in which case a repeat biopsy in 2 to 3 months might be indicated
  • Familial adenomatous polyposis
    • ​Approximate frequency of follow-up EGD would be every 2 to 4 years, in which case a repeat biopsy every 6 to 12 months if gastric adenomas or adenomas of the duodenum were demonstrated
BENEFIT APPLICATION

Subject to the terms and conditions of the applicable Evidence of Coverage, an upper GI endoscopy is covered under the medical benefits of the Company's Medicare Advantage products when the medical necessity criteria listed in this medical policy are met.

However, services that are identified in this policy as not medically necessary are not eligible for coverage or reimbursement by the Company.

Description

ENDOSCOPY

An upper gastrointestinal (GI) endoscopy involves examining the lining of the upper part of the GI tract, which includes the esophagus, stomach, and duodenum (first portion of the small intestine). The procedure involves the use of a thin, flexible tube called an endoscope, which has its own lens and light source to allow the display of images on a video monitor.

Several procedures may fall under the category of an upper endoscopy, including gastroscopy, esophagogastroduodenoscopy (EGD), and enteroscopy.

ESOPHAGOSCOPY

Esophagoscopy is a procedure in which an endoscope is inserted through the mouth or, very rarely, through the nares and into the esophagus. The endoscope uses a video chip to display magnified images on a video screen. The procedure allows visualization of the esophageal mucosa from the upper esophageal sphincter all the way to the esophagogastric junction (EGJ).

ESOPHAGOGASTRODUODENOSCOPY (EGD)

EGD, also known as upper GI endoscopy, upper endoscopy, or gastroscopy, refers to examination of the esophagus, stomach, and upper duodenum (first part of the small intestine) by means of a flexible fiber-optic endoscope with a tiny video camera and light on the end.

An EGD can evaluate, diagnose, and manage various GI problems, including difficult or painful swallowing, pain in the stomach or abdomen, GI bleed, ulcers, and tumors. Tiny instruments can be passed through an opening in the endoscope to obtain tissue samples, coagulate bleeding sites, dilate or stretch a narrowed area, or perform other treatments.

ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP)

An endoscopic retrograde cholangiopancreatography (ERCP) is used to diagnose, evaluate, and treat problems that affect the pancreas and bile duct system. An ERCP can be used when there is a blockage of the bile ducts by gallstones, tumors, scarring or other conditions that cause obstruction or narrowing of the ducts. Similarly, blockage of the pancreatic ducts from stones, tumors, or stricture can also be evaluated or treated by ERCP, which is useful in assessing causes of pancreatitis.

CONFOCAL LASER ENDOMICROSCOPY
Confocal laser endomicrosc​opy (CLE; also known as confocal fluorescent endomicroscopy and optic endomicroscopy) is an in vivo microscopic imaging of the mucosal epithelium during endoscopy to assess the GI mucosal histology. Light from a low-power laser illuminates the tissue. The same lens detects light reflected from the tissue through a pinhole. The term confocal refers to having both illumination and collection systems in the same focal plan. Light reflected and scattered that is not reflected through the pinhole is excluded from detection. This dramatically increases the resolution of the CLE images.

There are two CLE devices that have been cleared for marketing by the US Food and Drug Administration (FDA) through the 510k process. One is an endoscope-based system with a confocal probe incorporated onto the tip of a conventional endoscope. The other is a probe-based system in which the probe is placed through the biopsy channel of a conventional endoscope. The depth of view with the endoscopic system is up to 250 µm and about 120 µm with the probe-based system.

There are limited studies evaluating CLE for diagnosing pancreatic and biliary conditions.

References

Cohen D. Esophagogastroduodenoscopy. [Medscape Web site]. Updated 11/28/2022. Available at: http://emedicine.me dscape.com/article/1891879-overview [via subscription only]. Accessed February 17, 2026.

Misspelled WordKapetanos DJ. ERCP in acute biliary pancreatitis. World J Misspelled WordGastrointest Misspelled WordEndosc. 2010;2(1):25-28. 


Misspelled WordKaria K, Waxman I, Konda VJ, et al. Needle-based confocal Misspelled Wordendomicroscopy for pancreatic cysts: the current agreement in interpretation. Misspelled WordGastrointest Misspelled WordEndosc. 2016;83(5):924-927.

Misspelled WordNovitas, Inc. Medicare Services. Local Coverage Determination (LCD). L35350: Upper Endoscopy (Diagnostic and Therapeutic). (original effective 10/01/2015, revised 10/17/2019). Available at: LCD - Upper Gastrointestinal Endoscopy (Diagnostic and Therapeutic) (L35350)​. Accessed February 17, 2026.


Misspelled WordNovitas, Inc. Medicare Services. Local Coverage Article (LCA). A57414: Billing and Coding: Upper Gastrointestinal Endoscopy (Diagnostic and Therapeutic). (original effective 10/01/2019, revised 10/01/2025. Available at: Article - Billing and Coding: Upper Gastrointestinal Endoscopy (Diagnostic and Therapeutic) (A57414). Accessed February 17, 2026.

Misspelled WordSlivka A, Misspelled WordGan I, Misspelled WordJamidar P, et al. Validation of the diagnostic accuracy of probe-based confocal laser Misspelled Wordendomicroscopy for the characterization of indeterminate biliary strictures: results of a prospective multicenter international study. Misspelled WordGastrointest Misspelled WordEndosc. 2015;81(2):282-290.​


Coding

CPT Procedure Code Number(s)
MEDICALLY NECESSARY

43191, 43192, 43193, 43194, 43195, 43196, 43197, 43198, 43200, 43201, 43202, 43204, 43205, 43206, 43211, 43212, 43213, 43214, 43215, 43216, 43217, 43220, 43226, 43227, 43229, 43231, 43232, 43233, 43235, 43236, 43237, 43238, 43239, 43240, 43241, 43242, 43243, 43244, 43245, 43246, 43247, 43248, 43249, 43250, 43251, 43252, 43253, 43254, 43255, 43259, 43260, 43261, 43262, 43263, 43264, 43265, 43266, 43270, 43274, 43275, 43276, 43277, 43278

EXPERIMENTAL/INVESTIGATIONAL

0397T

ICD - 10 Procedure Code Number(s)
N/A

ICD - 10 Diagnosis Code Number(s)
Please See Attachment A.

HCPCS Level II Code Number(s)

MEDICALLY NECESSARY

C7541 Diagnostic endoscopic retrograde cholangiopancreatography (ercp), including collection of specimen(s) by brushing or washing, when performed, with endoscopic cannulation of papilla with direct visualization of pancreatic/common bile ducts(s)

C7542 Endoscopic retrograde cholangiopancreatography (ercp) with biopsy, single or multiple, with endoscopic cannulation of papilla with direct visualization of pancreatic/common bile ducts(s)

C7543 Endoscopic retrograde cholangiopancreatography (ercp) with sphincterotomy/papillotomy, with endoscopic cannulation of papilla with direct visualization of pancreatic/common bile ducts(s)

C7544 Endoscopic retrograde cholangiopancreatography (ercp) with removal of calculi/debris from biliary/pancreatic duct(s), with endoscopic cannulation of papilla with direct visualization of pancreatic/common bile ducts(s)

C7560 Endoscopic retrograde cholangiopancreatography (ercp) with removal of foreign body(s) or stent(s) from biliary/pancreatic duct(s) and endoscopic cannulation of papilla with direct visualization of pancreatic/common bile duct(s)


Revenue Code Number(s)
N/A



Coding and Billing Requirements


Policy History

Revisions From MA07.023m:​
​​04/01/2026

​This policy has been reviewed and reissued to communicate the Company’s continuing position on upper gastrointestinal endoscopy (diagnostic and therapeutic)​.
10/01/2025
​This version of the policy will become effective 10/01/2025.
 
Inclusion of a policy in a Code Update memo does not imply that a full review of
the policy was completed at this time.
 
The following ICD-10 codes have been added to this policy attachment A:
I27.840 Fontan-associated liver disease [FALD]
I27.841 Fontan-associated lymphatic dysfunction
I27.848 Other Fontan-associated condition
I27.849 Fontan related circulation, unspecified​

Revisions From MA07.023l:
07/01/2025

The version of this policy will become effective 07/01/2025.


The intent of this policy remains unchanged; however, the policy language has been updated. Information regarding sequential or periodic upper gastrointestinal endoscopy was further defined in the Guidelines section.

Revisions From MA07.023k:

​10/16/2024

The policy has been reviewed and reissued to communicate the Company’s continuing position on upper gastrointestinal endoscopy (diagnostic and therapeutic)​.​​

10/01/2024

Inclusion of a policy in a Code Update memo does not imply that a full review of
the policy was completed at this time.
 
This policy has been identified for the ICD-10 code update, effective 10/01/2024. 


The following ICD-10 code has been termed and deleted from Attachment A of this policy:


C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]

The following ICD-10 code has been added to Attachment A of ​​this policy:


C88.40 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] not having achieved remission


Revisions From MA07.023j:

01/02/2024

Inclusion of a policy in a Code Update memo does not imply that a full review of
the policy was completed at this time.
 
This policy has been identified for the HCPCS code update, effective 01/02/2024. 

The following HCPCS code has been added to this policy:


C7560 Endoscopic retrograde cholangiopancreatography (ercp) with removal of foreign body(s) or stent(s) from biliary/pancreatic duct(s) and endoscopic cannulation of papilla with direct visualization of pancreatic/common bile duct(s)​


Revisions From MA07.023i:

​01/01/2024
​Effective 01/01/2024 this policy applies to New Jersey Medicare Advantage (MA) lines of business.​​
05/08/2023This version of the policy will become effective 05/08/2023.

ICD-10 codes have been added to this policy in accordance with Novitas Local Coverage Determination L35350 and Local Coverage Article A57414.  ​

The following ICD-10 code has been added to this policy effective 1/9/2023:
D37.6 Neoplasm of uncertain behavior of liver, gallbladder and bile ducts

In addition to CPT codes (43260, 43261, 43262, 43263, 43264, 43265, 43274, 43277, 43278,  C7541, C7542, C7543, and C7544​), the following diagnosis code R93.2 is eligible when reported with the following CPT codes effective 1/9/2023:
43200, 43201, 43202, 43204, 43205, 43206, 43212, 43215, 43216, 43217, 43220, 43226, 43227, 43229, 43231, 43232, 43235, 43236, 43237, 43238, 43239, 43240, 43241, 43242, 43243, 43244, 43245, 43246, 43247, 43248, 43249, 43250, 43251, 43252, 43255, 43259, 43266, 43270, 43275, 43276

The following ICD-10 codes have been removed from this policy:  
    R63.30 Feeding difficulties, unspecified
    R63.31 Pediatric feeding disorder, acute
    R63.32 Pediatric feeding disorder, chronic


    Revisions from MA07.023h:

    01/01/2023
    I​nclusion of a policy in a Code Update memo does not imply that a full review of

    the policy was completed at this time.

     

    This policy has been identified for the HCPCS code update, effective 01/01/2023.


    The following HCPCS codes have been added to this policy:

    C7541  Diagnostic endoscopic retrograde cholangiopancreatography (ercp), including collection of specimen(s) by brushing or washing, when performed, with endoscopic cannulation of papilla with direct visualization of pancreatic/common bile ducts(s)


    C7542  Endoscopic retrograde cholangiopancreatography (ercp) with biopsy, single or multiple, with endoscopic cannulation of papilla with direct visualization of pancreatic/common bile ducts(s)


    C7543  Endoscopic retrograde cholangiopancreatography (ercp) with sphincterotomy/papillotomy, with endoscopic cannulation of papilla with direct visualization of pancreatic/common bile ducts(s)


    C7544  Endoscopic retrograde cholangiopancreatography (ercp) with removal of calculi/debris from biliary/pancreatic duct(s), with endoscopic cannulation of papilla with direct visualization of pancreatic/common bile ducts(s)


    Revisions From MA07.023g:

    11/17/2021This policy has been reissued in accordance with the Company's annual review process.
    10/01/2021This version of the policy is a result of code updates effective 10/01/2021. 

    Diagnosis codes K22.8 & R63.3 were deleted. 
     
    The following diagnosis codes were added:

    K22.81
    K22.82
    K22.89
    R63.30
    R63.31
    R63.32
    R63.39


    Revisions From MA07.023f:

    12/16/2020
    ​This policy has been reissued in accordance with the Company's annual review process.​​
    ​10/01/2020

    This version of the policy is a result of code updates effective 10/01/2020. 

    Diagnosis codes K20.8, K20.9, and K21.0 were deleted. 
     
    The following diagnosis codes were added:

    K20.80
    K20.81
    K20.90
    K20.91
    K21.00
    K21.01

    Revisions From MA07.023e:
    12/31/2019This policy has been reissued in accordance with the Company's annual review process.
    05/20/2019This version of the policy will become effective 05/20/2019. This policy was updated to include the Company's current experimental/investigational position for confocal laser endomicroscopy for the pancreas and bile duct system.

    The following CPT / HCPCS code has been added to this policy: 0397T (experimental/investigational)

    Revisions From MA07.023d:
    10/01/2018This policy has been identified for the ICD-10 CM code update, effective 10/01/2018.

    The following ICD-10 CM code has been termed from this policy:
      K83.0 Cholangitis

    The following ICD-10 CM codes have been added to this policy:
      K83.01 Primary sclerosing cholangitis
      K83.09 Other cholangitis

    Revisions From MA07.023c:
    01/31/2018The policy has been reviewed and reissued to communicate the Company’s continuing position on Upper Gastrointestinal Endoscopy (Diagnostic and Therapeutic).
    10/01/2017This policy has been identified for the ICD-10 CM code update, effective 10/01/2017.

    The following ICD-10 code has been termed from this policy:
    • K91.3

    The following ICD-10 CM codes have been added to this policy:
    • K91.30 Postprocedural intestinal obstruction, unspecified as to partial versus complete
    • K91.31 Postprocedural partial intestinal obstruction
    • K91.32 Postprocedural complete intestinal obstruction

    Revisions From MA07.023b:
    06/07/2017This policy has been reissued in accordance with the Company's annual review process.
    12/28/2016 In accordance with Medicare, the policy was updated with the following changes:

    Attachment A:
    • The following ICD-10 diagnosis codes: I86.4,K70.30. K70.31, K71.7, K74.3, K74.4, K74.5, K74.60, K74.69, K76.6 and K94.23 were added as medically necessary to the following CPT Codes: 43200, 43201, 43202, 43204, 43205, 43206, 43212, 43215, 43216, 43217, 43220, 43226, 43227, 43229, 43231, 43232, 43235, 43236, 43237, 43238, 43239, 43240, 43241, 43242, 43243, 43244, 43245, 43246, 43247, 43248, 43249, 43250, 43251, 43252, 43255, 43259, 43260, 43261, 43262, 43263, 43264, 43265, 43266, 43270, 43274, 43275, 43276, 43277, AND 43278
    • The following diagnosis R93.2 is no longer eligible when reported with CPT codes 43275 and 43276.

    Revisions From MA07.023a:
    10/01/2016This policy has been identified for the ICD-10 CM code update, effective 10/01/2016.
    The following ICD-10 CM been deleted from this policy:
      K85.0, K85.1, K 85.2, K 85.3, K85.8, K85.9 K86.8

    The following ICD-10 CM codes have been added to this policy:
      K85.00 , K85.01, K85.02, K85.10, K85.11, K85.12, K85.20, K85.21, K85.22, K85.30, K85.31, K85.32, K85.80, K85.81, K85.82, K85.90, K85.91, K85.92, K86.81, K86.89.

    Revisions From MA07.023:
    07/05/2016This new policy has been developed to communicate the Medicare Advantage coverage criteria for upper gastrointestinal endoscopy (Diagnostic and Therapeutic).

    10/1/2025
    10/1/2025
    4/1/2026
    MA07.023
    Medical Policy Bulletin
    Medicare Advantage
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    No