Notification



Notification Issue Date:



Medical Policy Bulletin


Title:Ipilimumab (Yervoy®)

Policy #:08.01.01h

This policy is applicable to the Company’s commercial products only. Policies that are applicable to the Company’s Medicare Advantage products are accessible via a separate Medicare Advantage policy database.


The Company makes decisions on coverage based on Policy Bulletins, benefit plan documents, and the member’s medical history and condition. Benefits may vary based on contract, and individual member benefits must be verified. The Company determines medical necessity only if the benefit exists and no contract exclusions are applicable.

When services can be administered in various settings, the Company reserves the right to reimburse only those services that are furnished in the most appropriate and cost-effective setting that is appropriate to the member’s medical needs and condition. This decision is based on the member’s current medical condition and any required monitoring or additional services that may coincide with the delivery of this service.

This Medical Policy Bulletin document describes the status of medical technology at the time the document was developed. Since that time, new technology may have emerged or new medical literature may have been published. This Medical Policy Bulletin will be reviewed regularly and be updated as scientific and medical literature becomes available. For more information on how Medical Policy Bulletins are developed, go to the About This Site section of this Medical Policy Web site.



Policy

Coverage is subject to the terms, conditions, and limitations of the member's contract.

MEDICALLY NECESSARY

Ipilimumab (Yervoy®) is considered medically necessary and, therefore, covered when the Dosing and Frequency Requirements listed in Attachment A and the following indications are met:

BRAIN METASTASES
As single-agent therapy or in combination with nivolumab (Opdivo®) for metastatic brain lesions in one of the following scenarios, if active against the primary tumor (melanoma).
  • Limited (1-3) metastatic lesions, when individual has recurrent disease
  • Multiple (more than 3) metastatic lesions, when individual has recurrent stable systemic disease

MELANOMA (METASTATIC OR UNRESECTABLE)
For metastatic or unresectable disease, in individuals ages 12 years and older, that occurs in one of the following scenarios:
  • First-line therapy in combination with nivolumab (Opdivo®) as an National Comprehensive Cancer Network (NCCN)-preferred regimen
  • First-line therapy as a single agent, when the individual has a documented failure, contraindication, or intolerance to nivolumab (Opdivo®)
  • Second-line or subsequent therapy as a single agent or in combination with nivolumab (Opdivo®) after disease progression or maximum clinical benefit from BRAF targeted therapy if anti-PD-1 therapy not previously used
  • Second-line or subsequent therapy after disease progression or maximum clinical benefit from BRAF targeted therapy if prior anti-PD-1 therapy resulted in disease control (complete response, partial response, or stable disease) and no residual toxicity, and disease progression/relapse occurred > 3 months after treatment discontinuation

MELANOMA (ADJUVANT TREATMENT AFTER COMPLETE RESECTION)
As a high-dose single agent for the adjuvant treatment of cutaneous melanoma with pathologic involvement of regional lymph nodes when the individual has a documented failure, contraindication, or intolerance to nivolumab (Opdivo®)* and when the following criteria are met:
  • Stage IIIA, B/C sentinel lymph node positive metastasis > 1 mm following active nodal basin surveillance or complete lymph node dissection (CLND)
  • Stage III disease with clinically positive node(s) following wide excision of primary tumor and a complete therapeutic lymph node dissection
  • Following CLND and/ or complete resection of nodal recurrence

*The National Comprehensive Cancer Network (NCCN) recommends nivolumab (Opdivo®) as the preferred adjuvant immunotherapy regimen for treatment for resected stage III (clinically positive nodes), IIIA and IIIB/C (sentinel node positive) melanoma.

RENAL CELL CARINCOMA (RCC)
For individuals with intermediate or poor risk, previously untreated advanced renal cell carcinoma, in combination with nivolumab (Opdivo®).

SMALL CELL LUNG CANCER (SCLC)
For use in combination with nivolumab (Opdivo®) as subsequent systemic therapy in individuals with performance status 0-2, for the treatment of primary progressive small cell lung cancer, or for relapse within 6 months following complete or partial response or stable disease with initial treatment.

EXPERIMENTAL/INVESTIGATIONAL

All other uses of ipilimumab (Yervoy®) are considered experimental/investigational and, therefore, not covered unless the indication is supported as an accepted off-label use, as defined in the medical policy on off-label coverage for prescription drugs and biologics.

DOSING AND FREQUENCY REQUIREMENTS

Refer to Attachment A for the Dosing and Frequency Requirements for ipilimumab (Yervoy®).

The Company reserves the right to modify the Dosing and Frequency Requirements listed in this policy to ensure consistency with the most recently published recommendations for the use of ipilimumab (Yervoy®). Changes to these guidelines are based on a consensus of information obtained from resources such as, but not limited to: the US Food and Drug Administration (FDA); Company-recognized authoritative pharmacology compendia; or published peer-reviewed clinical research. The professional provider must supply supporting documentation (i.e., published peer-reviewed literature) in order to request coverage for an amount of ipilimumab (Yervoy®) outside of the Dosing and Frequency Requirements listed in this policy. For a list of Company-recognized pharmacology compendia, view our policy on off-label coverage for prescription drugs and biologics.

Accurate member information is necessary for the Company to approve the requested dose and frequency of (for single drugs in a policy, state “this drug”) these drugs. If the member’s dose, frequency, or regimen changes (based on factors such as changes in member weight or incomplete therapeutic response), the provider must submit those changes to the Company for a new approval based on those changes as part of the precertification process. The Company reserves the right to conduct post-payment review and audit procedures for any claims submitted for ipilimumab (Yervoy®).

REQUIRED DOCUMENTATION

The individual's medical record must reflect the medical necessity for the drug. These medical records may include, but are not limited to: records from the professional provider's office, hospital, nursing home, home health agencies, therapies, and test reports.

The company may conduct reviews and audits of services to our members, regardless of the participation status of the provider. All documentation is to be available to the Company upon request. Failure to produce the requested information may result in a denial of the drug.

When coverage of ipilimumab (Yervoy®) is requested outside of the Dosing and Frequency Requirements listed in this policy, the prescribing professional provider must supply documentation (i.e., published peer-reviewed literature) to the Company that supports this request.
Guidelines

BLACK BOX WARNING

Refer to the specific manufacturer's prescribing information for any applicable Black Box Warnings.

THE EASTERN COOPERATIVE ONCOLOGY GROUP (ECOG) PERFORMANCE STATUS

The ECOG Performance Status was originally published in 1982 in the American Journal of Clinical Oncology*. ECOG states: "These scales and criteria are used by doctors and researchers to assess how an individual's disease is progressing, assess how the disease affects the daily living abilities of the individual, and determine appropriate treatment and prognosis. They are included here for health care professionals to access."
ECOG Performance Status
Grade
ECOG
0
Fully active, able to carry on all pre-disease performance without restriction
1
Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, eg, light house work, office work
2
Ambulatory and capable of all self care but unable to carry out any work activities. Up and about more than 50 percent of waking hours
3
Capable of only limited self care, confined to bed or chair more than 50 percent of waking hours
4
Completely disabled. Cannot carry on any self care: totally confined to bed or chair
5
Dead
*Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol.1982;5(6):649-655.

BENEFIT APPLICATION

Subject to the terms and conditions of the applicable benefit contract, ipilimumab (Yervoy®) is covered under the medical benefits of the Company's products when the medical necessity criteria and Dosing and Frequency Requirements listed in this medical policy are met.

US FOOD AND DRUG ADMINISTRATION (FDA) STATUS

Ipilimumab (Yervoy®) was approved by the FDA on March 25, 2011 for the treatment of unresectable or late-stage metastatic melanoma. Supplemental approvals for have since been issued by the FDA.

PEDIATRIC USE

The safety and effectiveness of ipilimumab (Yervoy®) have been established in pediatric individuals 12 years and older.

Description

Ipilimumab (Yervoy®), an intravenously delivered agent, is a human cytotoxic T-lymphocyte antigen 4 (CTLA-4) blocking antibody indicated for the treatment of unresectable or metastatic melanoma and for cutaneous melanoma with lymph node involvement. By blocking the T-lymphocyte, ipilimumab (Yervoy®) may allow the body's immune system to attack cells in the melanoma tumor.

Melanoma can arise in the cutaneous regions (skin) or in the mucosal regions (mucus membranes, such as the gastrointestinal or genitourinary tracts). Cutaneous melanoma is the deadliest form of skin cancer, a cancer that is characterized by the uncontrolled growth of melanocytes (pigment cells). Mucosal melanoma is the rarer form of the two types of melanoma and exhibits a poorer prognosis. Melanoma can be contained to one site or it can spread locally to areas within the same region. Metastatic melanoma is the terminology used to describe a setting where the melanoma spreads beyond the skin surface or mucosal epithelium lining and invades other organs of the body.

According to the American Joint Commission on Cancer (AJCC), individuals with melanoma are categorized into three groups:
  • Stage I-II -- no evidence of metastases; localized
  • Stage III -- regional disease
  • Stage IV -- distant metastatic disease

PEER-REVIEWED LITERATURE

SUMMARY
Unresectable or Metastatic Melanoma, as a Single Agent

The FDA granted approval of ipilimumab (Yervoy®) based on a double-blind, Phase III study of 676 individuals who had been previously treated with other chemotherapeutic agents and had a diagnosis of unresectable or metastatic melanoma. Ninety-eight percent of these individuals also had Eastern Cooperative Oncology Group (ECOG) performance status scores of 0 and 1. As part of the study, individuals received ipilimumab (Yervoy®) 3 mg/kg as an intravenous infusion administered over 90 minutes every three weeks for a total of four doses. The overall survival rate of the participants significantly improved compared to other therapeutic agents.

Unresectable or Metastatic Melanoma, in Combination with Nivolumab (Opdivo®)

The combined use of ipilimumab (Yervoy®) and nivolumab (Opdivo®) was FDA approved based on a Phase III, randomized (1:1:1), double-blind, multicenter, study of 945 individuals with untreated unresectable or metastatic melanoma. The three arms of the study consisted of:
    1. Nivolumab (Opdivo®) 1 mg/kg with ipilimumab (Yervoy®) 3 mg/kg every 3 weeks for 4 doses, followed by nivolumab (Opdivo®) 3 mg/kg as a single agent every 2 weeks (Combination arm),
    2. Nivolumab (Opdivo®) 3 mg/kg every 2 weeks (nivolumab [Opdivo®] arm)
    3. Ipilimumab (Yervoy®) 3 mg/kg every 3 weeks for 4 doses followed by placebo every 2 weeks (ipilimumab [Yervoy®] arm).

Progression-free survival (PFS) was defined as the time between the date of randomization and the date of documented progression or death, whichever occurred first. PFS in the combination arm was 11.5 months, as compared with 6.9 months in the nivolumab (Opdivo®) arm and 2.9 months in the ipilimumab (Yervoy®) arm. PFS was statistically significantly longer in the Combination arm than in the ipilimumab (Yervoy®) arm. PFS was also statistically significantly longer in the nivolumab (Opdivo®) arm than in the ipilimumab (Yervoy®) arm.

Adjuvant Treatment of Individuals with Cutaneous Melanoma

The safety and efficacy of ipilimumab (Yervoy®) was studied for the adjuvant treatment of melanoma through a randomized (1:1), double-blind, placebo-controlled trial in 951 individuals with resected Stage IIIA (>1 mm nodal involvement), IIIB, and IIIC (with no in-transit metastases) histologically confirmed cutaneous melanoma. Individuals received ipilimumab (Yervoy®) 10 mg/kg or placebo as an intravenous infusion every 3 weeks for 4 doses, followed by ipilimumab (Yervoy®) 10 mg/kg or placebo every 12 weeks from Week 24 to Week 156 (3 years) or until documented disease recurrence or unacceptable toxicity. One primary efficacy outcome was recurrence-free survival (RFS) defined as the time between the date of randomization and the date of first recurrence (local, regional, or distant metastasis) or death, whichever occurs first. RFS was significantly improved in those to received ipilimumab (Yervoy®) (49% at a median of 26 months) compared to those who received placebo (62% at a median of 17 months). Another primary efficacy outcome was overall survival; final analysis is still pending for this study.

The efficacy of nivolumab (Opdivo®) versus ipilimumab (Yervoy®) for adjuvant therapy in individuals with resected advanced melanoma was studied in a randomized, double-blind, phase 3 trial. 906 individuals who were undergoing complete resection of stage IIIB, IIIC, or IV melanoma were randomized to receive an intravenous infusion of either nivolumab (Opdivo®) 3 mg/kg every 2 weeks or ipilimumab (Yervoy®) 10 mg/kg every 3 weeks for four doses and then every 12 weeks. Individuals were treated for up to 1 year or until disease recurrence, a report of unacceptable toxicity, or withdrawal of consent. The primary endpoint was recurrence-free survival in the intention to treat population. At a minimum follow up of 18 months, the 12 month rate of recurrence free survival was 70.5% in the nivolumab (Opdivo®) group versus 60.8% in the ipilimumab (Yervoy®) group. Treatment related grade 3 or 4 adverse events were reported in 14.4% of the individuals in the nivolumab (Opdivo®) group versus 45.9% in the ipilimumab (Yervoy®) group. Treatment was discontinued in 9.7% of nivolumab (Opdivo®) treated individuals and 42.6% of ipilimumab (Yervoy®) treated individuals due to adverse effects, and 2 deaths related to toxicity were reported in the ipilimumab (Yervoy®) group more than 100 days after treatment. These results indicated that therapy with nivolumab (Opdivo®) had significantly longer recurrence free survival with a lower rate of grade 3 or 4 adverse events that adjuvant therapy with ipilimumab (Yervoy®).

Due to the results of this study, the National Comprehensive Cancer Network (NCCN) recommends nivolumab (Opdivo®) as the preferred adjuvant immunotherapy regimen for treatment for resected stage III (clinically positive nodes), IIIA and IIIB/C (sentinel node positive) melanoma.

Advanced Renal Cell Carcinoma (RCC)

The efficacy of ipilimumab (Yervoy®) was studied in a randomized (1:1), open-label trial in intermediate/poor risk individuals with previously untreated advanced RCC who had at least 1 or more of 6 prognostic risk factors as per the IMDC criteria (less than one year from time of initial renal cell carcinoma diagnosis to randomization, Karnofsky performance status <80%, hemoglobin less than the lower limit of normal, corrected calcium of greater than 10 mg/dL, platelet count greater than the upper limit of normal, and absolute neutrophil count greater than the upper limit of normal).
The two arms of the study were:
  • nivolumab (Opdivo®) 3 mg/kg plus ipilimumab (Yervoy®) 1 mg/kg (n=425) IV every 3 weeks for 4 doses followed by nivolumab (Opdivo®) monotherapy 3 mg/kg every two weeks until disease progression or unacceptable toxicity.
  • sunitinib (n=422) 50 mg orally daily for 4 weeks followed by 2 weeks off, every cycle. Treatment continued until disease progression or unacceptable toxicity.

The primary efficacy outcomes were OS, PFS, and confirmed ORR. The results of this trial demonstrated statistically significant improvement in median OS (not estimated vs. 25.9 months) and ORR (41.6% vs. 26.5%) for individuals randomized to nivolumab (Opdivo®) plus ipilimumab (Yervoy®) as compared with sunitinib. Furthermore, the OS benefit was observed regardless of PD-L1 expression level. However, this trial did not demonstrate a statistically significant improvement in median PFS (11.6 months vs. 8.4 months) for individuals randomized to nivolumab (Opdivo®) plus ipilimumab (Yervoy®) as compared with sunitinib.

OFF-LABEL INDICATIONS

There may be additional indications contained in the Policy section of this document due to evaluation of criteria highlighted in the Company’s off-label policy, and/or review of clinical guidelines issued by leading professional organizations and government entities.
References


American Hospital Formulary Service (AHFS). Drug Information 2018. Ipilimumab (Yervoy). [Lexicomp Online Web Site] Updated 02/27/2018. Available at: http://online.lexi.com/lco/action/doc/retrieve/docid/complete_ashp/3596963 [via subscription only]. Accessed March 14, 2018.

American Hospital Formulary Service (AHFS). Drug Information 2018. Nivolumab (Opdivo). [Lexicomp Online Web Site] Updated 02/27/2018. Available at: http://online.lexi.com/lco/action/doc/retrieve/docid/complete_ashp/5756161 [via subscription only]. Accessed March 14, 2018.

Carvajal RD, Hamid O, Ariyan C. Mucosal melanoma. Updated: 01/08/2018. UpToDate Web Site. Available at: http://www.uptodate.com/contents/mucosal-melanoma?source=search_result&search=mucosal+melanoma&selectedTitle=1%7E10 [via subscription only]. Accessed March 15, 2018.

Elsevier’s Clinical Pharmacology Compendium. Ipilimumab (Yervoy). 04/17/2018. [Clinical Pharmacology Web site]. Available at: https://www.clinicalkey.com/pharmacology/monograph/3721?sec=monindi&n=YERVOY [via subscription only]. Accessed April 18, 2018..

Elsevier’s Clinical Pharmacology Compendium. Nivolumab (Opdivo). 03/07/2018. [Clinical Pharmacology Web site]. Available at: https://www.clinicalkey.com/pharmacology/monograph/3973?sec=monindi&n=Opdivo. [via subscription only]. Accessed March 15, 2018.

Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711-723.

Ipilimumab (Yervoy) Package Insert. Bristol-Myers Squibb; Princeton, NJ. Updated 04/2018. Available at: http://www.yervoy.com/ . Accessed April 16, 2018.

Larkin J, Chiarion-Sileni V, Gonzalez R, et al. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. N Engl J Med. 2015 Jul 2;373(1):23-34. doi: 10.1056/NEJMoa1504030. Epub 2015 May 31.

Lexi-Drugs Compendium. Ipilimumab (Yervoy). 03/12/2018. [Lexicomp Online Web site]. Available at: http://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/2934459 [via subscription only]. Accessed March 15, 2018.

Lexi-Drugs Compendium. Nivolumab (Opdivo). 03/09/2018. [Lexicomp Online Web site]. Available at: http://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/5467454 [via subscription only]. Accessed March 15, 2018.

Margolin K, Ernstoff MS, Hamid O, et al. Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial. Lancet Oncol. 2012;13(5):459-65.

National Comprehensive Cancer Network (NCCN). NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Version 1.2017; revised 08/18/2017. CNS Cancers. [NCCN Website]. Available at: https://www.nccn.org/professionals/physician_gls/pdf/cns.pdf. [via free subscription only]. Accessed March 6, 2018.
National Comprehensive Cancer Network (NCCN). NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Version 2.2018; revised 01/19/2018. Melanoma. [NCCN Website]. Available at: https://www.nccn.org/professionals/physician_gls/pdf/melanoma.pdf [via free subscription only]. Accessed March 6, 2018.

National Comprehensive Cancer Network (NCCN). Drugs and Biologics Compendium. Ipilimumab. [NCCN Website]. Available at: http://www.nccn.org/professionals/drug_compendium/content/contents.asp [via subscription only]. Accessed April 16, 2018.

National Comprehensive Cancer Network (NCCN). Drugs and Biologics Compendium. Nivolumab. [NCCN Website]. Available at:
http://www.nccn.org/professionals/drug_compendium/content/contents.asp [via subscription only]. Accessed March 6, 2018.

Nivolumab (Opdivo) Package Insert. Bristol-Myers Squibb; Princeton, NJ. Updated 03/2018. Available at: http://packageinserts.bms.com/pi/pi_opdivo.pdf . Accessed March 6, 2018.

Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol.1982;5(6):649-655.

Postow MA, Hamid O, Carvajal RD. Mucosal melanoma: pathogenesis, clinical behavior, and management. Curr Oncol Rep. 2012;14(5):441-8.

Tanabe KK, Tyler D. Cutaneous melanoma: In transit metastases. [UpToDate Web Site]. Updated: 02/05/2018. Available at: http://www.uptodate.com/contents/cutaneous-melanoma-management-of-in-transit-metastase[via subscription only]. Accessed March 15, 2018.

Truven Health Analytics Inc. Micromedex Solutions. Ipilimumab (Yervoy). Updated 02/16/2018. Available at: http://www.micromedexsolutions.com/micromedex2/librarian [via subscription only]. Accessed March 15, 2018.

Truven Health Analytics Inc. Micromedex Solutions. Nivolumab (Opdivo). Updated 03/06/2018. Available at: http://www.micromedexsolutions.com/micromedex2/librarian [via subscription only]. Accessed March 15, 2018.

US Food and Drug Administration (FDA). Ipilimumab (Yervoy) Prescribing Information. Updated 04/2018. Available at: http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm . Accessed April 16, 2018.

US Food and Drug Administration (FDA). Center for Drug Evaluation and Research. Drugs @FDA. Nivolumab (Opdivo) Approval letter and Prescribing Information. [FDA Website]. Updated 03/05/2018. Available at: http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm . Accessed March 6, 2018.





Coding

Inclusion of a code in this table does not imply reimbursement. Eligibility, benefits, limitations, exclusions, precertification/referral requirements, provider contracts, and Company policies apply.

The codes listed below are updated on a regular basis, in accordance with nationally accepted coding guidelines. Therefore, this policy applies to any and all future applicable coding changes, revisions, or updates.

In order to ensure optimal reimbursement, all health care services, devices, and pharmaceuticals should be reported using the billing codes and modifiers that most accurately represent the services rendered, unless otherwise directed by the Company.

The Coding Table lists any CPT, ICD-9, ICD-10, and HCPCS billing codes related only to the specific policy in which they appear.

CPT Procedure Code Number(s)

N/A


Professional and outpatient claims with a date of service on or before September 30, 2015, must be billed using ICD-9 codes. Professional and outpatient claims with a date of service on or after October 1, 2015, must be billed using ICD-10 codes.

Facility/Institutional inpatient claims with a date of discharge on or before September 30, 2015, must be billed with ICD-9 codes. Facility/Institutional inpatient claims with a date of discharge on or after October 1, 2015, must be billed with ICD-10 codes.


ICD - 10 Procedure Code Number(s)

N/A


Professional and outpatient claims with a date of service on or before September 30, 2015, must be billed using ICD-9 codes. Professional and outpatient claims with a date of service on or after October 1, 2015, must be billed using ICD-10 codes.

Facility/Institutional inpatient claims with a date of discharge on or before September 30, 2015, must be billed with ICD-9 codes. Facility/Institutional inpatient claims with a date of discharge on or after October 1, 2015, must be billed with ICD-10 codes.


ICD -10 Diagnosis Code Number(s)

See Attachment B


HCPCS Level II Code Number(s)

J9228 Injection, ipilimumab, 1 mg


Revenue Code Number(s)

N/A

Coding and Billing Requirements


Cross References

Attachment A: Ipilimumab (Yervoy®)
Description: Dosing and Frequency Requirements For Ipilimumab (Yervoy®)

Attachment B: Ipilimumab (Yervoy®)
Description: ICD-10 Diagnosis codes




Policy History

Revisions from 08.01.01h
10/01/2018This policy has been identified for the ICD-10 CM code update, effective 10/01/2018.

The following CD-10 CM codes have been termed from this policy:
C43.11 Malignant melanoma of right eyelid, including canthus

C43.12 Malignant melanoma of left eyelid, including canthus


The following ICD-10 CM codes have been added to this policy:
C43.111 Malignant melanoma of right upper eyelid, including canthus

C43.112 Malignant melanoma of right lower eyelid, including canthus

C43.121 Malignant melanoma of left upper eyelid, including canthus

C43.122 Malignant melanoma of left lower eyelid, including canthus





08.01.01g
06/04/2018This policy has undergone a routine review and the medical necessity criteria have been revised to reflect the United States Food and Drug Administration (FDA) labeling and National Comprehensive Cancer Network (NCCN) compendia.

Advanced renal cell carcinoma was added as a new covered indication.

The following diagnosis code has been removed from the policy:
C45.0 Mesothelioma of pleura

Effective 10/05/2017 this policy has been updated to the new policy template format.
Version Effective Date: 10/01/2018
Version Issued Date: 10/01/2018
Version Reissued Date: N/A

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